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ar a2a agonist lexiscan (Gilead Sciences)

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Gilead Sciences ar a2a agonist lexiscan
Ar A2a Agonist Lexiscan, supplied by Gilead Sciences, used in various techniques. Bioz Stars score: 97/100, based on 314 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/a2a+ar+agonist/Lexiscan/pmc08935726-299-2-4
Average 97 stars, based on 314 article reviews

ar a2a agonist lexiscan - by Bioz Stars, 2026-09

97/100 stars

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Activation Assay:

Article Title: A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier
Article Snippet: .. Here, we show that activation of the A2A adenosine receptor (AR) with an FDA-approved A2A AR agonist (Lexiscan) rapidly and potently decreased P-gp expression and function in a time-dependent and reversible manner. ..

Article Title: A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier
Article Snippet: .. More recently, we showed that activation of A2A AR with a broad-spectrum AR agonist or an FDA-approved specific A2A AR agonist, 2-{4-[(methylamino)carbonyl]-1H-pyrazol-1-yl}adenosine (Lexiscan), increased accumulation of drugs into the brain in a time- and dose-dependent manner ( 45 ). ..

Expressing:

Imaging:

Article Title: A2A adenosine receptor regulates the human blood brain barrier permeability
Article Snippet: .. 2) We used an FDA-approved A2A AR agonist, Lexiscan (used in humans for cardiac perfusion imaging), to determine its potential as a BBB permeabilizing (or brain)-drug delivery tool. .. Here, we report that activation of the A2A AR on primary human brain endothelial cells triggers a rapid increase in RhoA activity, re-organization of the actin cytoskeleton and consequently disruption of the endothelial cell-to-cell junctions, leading to the increased paracellular permeability.